Proteases and oxidants in experimental pulmonary inflammatory injury.
نویسندگان
چکیده
منابع مشابه
Experimental pulmonary inflammatory injury in the monkey.
Inflammatory pulmonary injury was induced in Macaca mulatta rhesus monkeys by the intrabronchial instillation of the formylated peptide norleu-leu-phe (FNLP) or phorbol myristate acetate (PMA). Indicators of pulmonary injury included an increase in mean protein content of bronchoalveolar lavage (BAL) fluid from 0.51 mg/ml in untreated animals to 3.74 mg/ml and 6.64 mg/ml in FNLP- and PMA-treate...
متن کاملMicrobial Killing: Oxidants, Proteases and Ions
There is accumulating evidence that two aspects of the innate immune response, the respiratory burst and secretion of proteases, are intimately intertwined. A recent study suggests that K(+) may be the missing link. Is it time to merge signal transduction with biophysics?
متن کاملInflammatory response to infectious pulmonary injury.
This review describing the inflammatory response to infectious pulmonary injury is focused on the innate immunity of the distal lung to bacterial pneumonia. The fact that the inflammatory response varies to some extent with the bacterial strain responsible for the infection is emphasised. The key cellular components present in the distal lung are described. The major role of alveolar macrophage...
متن کاملPulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses.
To test whether pulmonary and extrapulmonary acute lung injury (ALI) of identical mechanical compromise would express diverse morphological patterns and immunological pathways. For this purpose, a model of pulmonary (p) and extrapulmonary (exp) ALI with similar functional changes was developed and pulmonary morphology (light and electron microscopy), cytokines levels, and neutrophilic infiltrat...
متن کاملhydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction
hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1984
ISSN: 0021-9738
DOI: 10.1172/jci111303